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10.2147/DDDT.S343928 150 WangH

Aldehyde dehydrogenase 1A1 (ALDH1A1), an enzyme expressed by dopaminergic neurons for the detoxification of these neurons, is controlled by retinoic acid and plays a crucial role of aldehyde dehydrogenase enzymes in the survival of dopaminergic neurons by controlling the ALDH1A1 enzyme in PD (103)

Almost all plasma urate is filtered at the glomerulus and most of the filtered load undergoes proximal tubular reabsorption, with secretion and postsecretory reabsorption also regulating the ultimate uric acid elimination of normally ~10% of the filtered load ( Figure 1 - 6 )

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